V60L , rs1805005 red hair gene

General discussions regarding DNA and its uses in genealogy research

Posts: 2152
Joined: Fri Mar 16, 2012 5:43 pm

MtDNA:
U5b2b
PostPosted: Thu Aug 06, 2015 5:56 pm
https://mathildasanthropologyblog.wordp ... ir-colour/

Both African and non-African data suggest that the time to the most recent common ancestor is ª1 million years and that the age of the global 314 variant is 650,000 years. On this time scale, ages for the Eurasian distributed Val60Leu, Val92Met, and Arg163Gln variants are 250,000–100,000 years; the ages for African silent variants—Leu106Leu, Cys273Cys, and Phe300Phe—are 110,000–40,000 years. For the European red hair–associated Arg151Cys and Arg160Trp variants, we estimate an age of ª80,000 years; for Asp294His, and Ser316Ser, we estimate an age of <30,000 years. SDs are approximately half these expectations.

These ages are entirely compatible with age distributions estimated for African and non-African mutations in other nuclear genes (Harding et al. 1997; Zietkiewicz et al. 1998). The ages estimated for the Arg151Cys and Arg160Trp red hair–associated variants are consistent with a widespread European distribution, as we also observed.

Red hair associated MC1R variants are Arg151Cys, Asp294His and Arg160Trp (two are 80,000 years old, one 30,000). Val60Leu is associated with fair or light brown hair and is estimated at 250,000 ot 100,000 years.

Posts: 2152
Joined: Fri Mar 16, 2012 5:43 pm

MtDNA:
U5b2b
PostPosted: Sun Mar 25, 2018 6:34 pm
dartraighe wrote:https://mathildasanthropologyblog.wordpress.com/2008/10/10/stuides-on-the-mc1r-site-for-skin-and-hair-colour/

Both African and non-African data suggest that the time to the most recent common ancestor is ª1 million years and that the age of the global 314 variant is 650,000 years. On this time scale, ages for the Eurasian distributed Val60Leu, Val92Met, and Arg163Gln variants are 250,000–100,000 years; the ages for African silent variants—Leu106Leu, Cys273Cys, and Phe300Phe—are 110,000–40,000 years. For the European red hair–associated Arg151Cys and Arg160Trp variants, we estimate an age of ª80,000 years; for Asp294His, and Ser316Ser, we estimate an age of <30,000 years. SDs are approximately half these expectations.

These ages are entirely compatible with age distributions estimated for African and non-African mutations in other nuclear genes (Harding et al. 1997; Zietkiewicz et al. 1998). The ages estimated for the Arg151Cys and Arg160Trp red hair–associated variants are consistent with a widespread European distribution, as we also observed.

Red hair associated MC1R variants are Arg151Cys, Asp294His and Arg160Trp (two are 80,000 years old, one 30,000). Val60Leu is associated with fair or light brown hair and is estimated at 250,000 ot 100,000 years.



How does "Out of Africa" 60,000 years ago explain a variant for hair colour that occurs in western European populations, when that variant is estimated to be 250,000-100,000 years old? Africans do not have red-hair variants.




David Reich has doubts on Africa as the origin of Anatomical Modern Humans
"He proposes an alternative scenario: the first migration of hominins (Homo erectus) into Eurasia 1.8m years ago led to substantial evolution of archaic humans there too. Some of them then moved back into north Africa, where they became the primary founders of the population that later evolved into modern humans. While this is unproven, Reich writes, “the evidence for many lineages and admixtures should have the effect of shaking our confidence in what to many people is now an unquestioned assumption that Africa has been the epicentre of all major events in human evolution.”

Posts: 2341
Joined: Sun Mar 18, 2012 7:08 am
Location: Pisa (Italy)
YDNA:
R- Z2110 (KV7Y2)
MtDNA:
K1a1b1e/HQ176413
PostPosted: Mon Mar 26, 2018 5:14 am
dartraighe wrote:David Reich has doubts on Africa as the origin of Anatomical Modern Humans
"He proposes an alternative scenario: the first migration of hominins (Homo erectus) into Eurasia 1.8m years ago led to substantial evolution of archaic humans there too. Some of them then moved back into north Africa, where they became the primary founders of the population that later evolved into modern humans. While this is unproven, Reich writes, “the evidence for many lineages and admixtures should have the effect of shaking our confidence in what to many people is now an unquestioned assumption that Africa has been the epicentre of all major events in human evolution.”


It si just the theory of Shi Huang and his school that I am supporting (with German Dziebel) also this time against all... ahahahahahahaah

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